I just rewatched Sale's innings from game one. His command appeared to improve as he went, but he was also hurt by at least one missed call. Still barely any changeups (3 total), and still a gigantic split as a result.
To RHH in his start against Houston, he gave up: walk, single, 6-3, single, single, HBP, strikeout, groundout, single. So, that's 4/7 with a walk and a HBP. Yikes. They mostly just lay off the slider, although he did get three swinging strikes against it, so it looks to me like the pitch itself (it's shape) is fine. Bottom line: until he can regain trust in the changeup, he's a total liability against RHH.
In contrast, here was his performance against LHH: flyout, sac fly, popup, lineout (Kiké diving catch), soft, shift-beating single, strikeout. 1/6 with some help from the defense, but also a bunch of weak contact (even the diving catch was more of a Texas leaguer than a scalded line drive), and a wild pitch that advanced Altuve to third to score on the Alvarez sac fly.