Here’s another way of looking at it.
26-man locks (no options):
Sale, Kluber, Pivetta, Paxton, Jansen, Martin, Rodriguez, Brasier, Bleier (9)
Kiké, Devers, Turner, Duvall, Mondesi, McGuire, Refsnyder, Arroyo (8)
Virtual locks:
Yoshida, Verdugo, Whitlock, Houck, Casas, Schreiber (6)
Optionables with MLB experience:
Bello, Dalbec, Duran, Crawford, Wong, Winckowski, Mills, Ort, Kelly
60-day IL
Story
The first 23 players are locks for the active roster, if healthy. You need a second catcher, so either Wong starts in Boston or you use Alfaro in Story's spot on the 40-man — either way that's 24. You need a 13th position player, and as it stands that's likely Dalbec, Duran or Andrus/Iglesias (25). Bello is arguably our best pitcher next year, so I'd personally have him up too. If everyone else is healthy, that's 26. When Story returns, that'd be 27. (I'm aware Mondesi might not be ready for opening day, but he's reportedly only expected to miss a little time if at all).
I can't really make this roster work with Pivetta, so I'm trading him off it for some cool non-40 man prospects. Although I guess technically they could take on a 40-man guy if they're removing Pivetta. If they are keeping Pivetta, I think I staple Kluber/Paxton together & make Houck more of a general reliever, but I would want him available for 2 innings each Sale start.
Assuming health for all except Story, this would be my desired roster permutations...
SP
1 Sale
2 Bello
3 Paxton
4 Whitlock
5 Kluber
Major League Depth - Houck
40-Man Depth - Crawford/Mata/Walter/Winckowski/Murphy
Staple
Houck - would like to see him mostly attached to the Paxton starts for 3 innings or so, with the ability to throw an inning in the Sale start as needed (it's the only reason I have Paxton ahead of Whitlock)
RP
CL Jansen
SU Martin
SU Schreiber
LH Joely
LH Bleier
RH Brasier (happy to move on from him, too - assuming health there would probably need to be another shuttle relief spot)
RH Kelly
40-Man Depth - Mills/Ort/Mata/Crawford/Walter/Murphy/Winckowski
Non-40 Depth - Altavilla/Sherriff/Dermody/Sharp/Broadway/Mosqueda/Theo/Gudino/etc.
C
Reese McGuire - start against righties
Connor Wong - start against lefties
Non-40 Depth - Alfaro/Hernandez/Hamilton/Scott
1B
Casas - start against all, occasional off day against tough lefties
Turner - occasional start against tough lefties
Major League Depth - Duvall/Valdez/Arroyo
40-Man Depth - Dalbec
2B
Valdez - start against most righties (assuming Spring Training goes well & he's ready...I have a feeling he will be, but who knows?)
Arroyo - start against lefties
Major League Depth - Kiké (if Mondesi is playing, he should be the SS)
40-Man Depth - Hamilton/Rafaela/Duran (let's try him there in AAA)
Non-40 Depth - Goodrum/Koss/Lugo/Fitzgerald/Sogard
SS
Mondesi - start against most righties
Kiké - start against lefties
Major League Depth - Arroyo
40-Man Depth - Hamilton/Rafaela
Non-40 Depth - Goodrum/Koss/Lugo/Fitzgerald/Sogard
3B
Devers - start against all, occasional day off or semi-rest day at DH
Major League Depth - Turner/Arroyo/Valdez
40-Man Depth - Dalbec
Non-40 Depth - Koss/Goodrum/Lugo
LF
Yoshida - start against all righties, some lefties
Refnsyder - start against some lefties
Major League Depth - Verdugo
40-Man Depth - Abreu/Duran/Rafaela
Non-40 Depth - Tapia/Allen/Scott
CF
Kiké - start against most righties
Duvall - start against lefties, some righties
Major League Depth - Meh
40-man Depth - Rafaela/Duran/Goodrum/Abreu/Hamilton
Non-40 Depth - Allen/Tapia
RF
Verdugo - start against righties, some lefties
Refsnyder - start against lefties when not starting in left
Major League Depth - Duvall
40-Man Depth - Rafaela/Abreu/Duran/Hamilton
Non-40 Depth - Tapia/Allen/Scott
DH
Turner - start most days, including all lefties when not at 1B or 3B
Major League Depth - Duvall/Valdez/Devers/Yoshida/etc.
40-Man Depth - Dalbec/etc.
Non-40 Depth - Alfaro/etc.
They will likely do a ton of swapping people around on a day to day basis & probably not really have a set lineup against lefties & righties, but generic default let's try...
v. Righties
LF Yoshida (L)
DH Turner (R)
3B Devers (L)
1B Casas (L)
RF Verdugo (L)
CF Kiké (R)
2B Valdez (L)
SS Mondesi (B)
C McGuire (L)
Bench
Duvall (R)
Arroyo (R)
Refsnyder (R)
Wong (R)
v. Lefties
SS Kiké (R)
3B Devers (L)
DH Turner (R)
1B Casas (L)
CF Duvall (R)
2B Arroyo (R)
LF Yoshida (L) or RF Verdugo (L)
LF/RF Refsnyder (R)
C Wong (R)
Bench
Yoshida (L) or Verdugo (L)
Mondesi (B)
Valdez (L)
McGuire (L)