Hendu is right. Normally I want to temper a prediction because every game makes me somewhat nervous. Heck, to my friends, I even explained a scenario where Jacksonville could have made it difficult for NE two weeks ago.
But...... The Patriots are clearly the superior team. In virtually every way. Some numbers...
Points per game
NE - 37.3 (#2)
Ind - 19.8 (#24)
Yards per game
NE - 423.8 (#1)
Ind - 334.8 (#23)
Third down conversions
NE - 53.3% (#1)
Ind - 42.4% (#10)
Giveaways
NE - 2 (#1)
Ind - 12 (#31)
Points allowed per game
NE - 19.0 (#7)
Ind - 22.6 (#16)
Yards allowed per game
NE - 342.5 (#12)
Ind - 398.8 (#28)
Third down conversions allowed per game
NE - 38.9 (#15)
Ind - 38.9 (#15)
Takeaways
NE - 7 (#15)
Ind - 5 (#21)
Record
NE - 4-0
Ind - 3-2
Pro-football-reference.com strength of schedule rating
NE - 0.4
Ind - -2.1
I mean, this should be a total and complete destruction of Indianapolis by the Patriots. And, barring a catastrophic injury, I think that's exactly what will happen. If Indy loads up against the run, the Pats will shred them through the air. If Indy plays a lot of nickel, Blount and Lewis will run wild. Indy doesn't get much pressure on the QB, and that means Brady should have time to do what he wants. If they try to get extra pressure by blitzing, well, that leaves their mediocre cover guys in one on one matchups against more talented players, and Brady is deadly against the blitz. He has a passer rating this year of 144.7 against the blitz: 20-26 (76.9%), 243 yds, 9.4 ypa, 6 td, 0 int. So good luck to them if they try that.
Long story short, unless NE has an uncharacteristically bad day, I don't see any way they score fewer than 35 points. And I don't see Indy putting up nearly that many points, even if Luck returns.
Final score prediction: NE 41, Ind 20. Another 20+ point hammering of Indy by the Patriots.